The Dantzler Plantation House is significant as an outstanding local example of mid-nineteenth-century Greek Revival architecture with various later alterations and additions designed to emulate this Greek Revival style, as well as for its significant and intriguing interior modifications that reflect the changing fortunes of its owners and the various uses of plantation architecture throughout the nineteenth and early twentieth centuries. Because of the destruction wrought on such properties in Orangeburg County during the Civil War, such an intact property is rare for the county. The property is also noteworthy for its association with the Dantzler family, one of the most prominent families of Orangeburg County from the eighteenth century to the present, and it remains in family hands. The house, constructed ca. 1846-1850, is a porticoed, two-story Greek Revival raised cottage of frame construction, set on a partially enclosed, brick pier foundation. The main block of the house is unique for its remarkable depth (triple pile) in comparison to its width (only five bays wide). The two interior double chimneys and the two exterior chimneys at the rear of the main block are composed of soft brick that was made on the property and also used in the construction of the foundation.

Listed in the National Register March 1, 2007. The full text of the nomination and additional photos are available at the SCDAH.